Understanding the role of supracollicular nuclei in the generation of basal sympathetic vasomotor tone.

在患有心血管疾病的患者中，可以观察到大脑中调节血压的部分活动增加，包括高血压和心力衰竭。在某些情况下，这种活动增加实际上可能会导致高血压。在所有情况下，这种活动增加都会导致严重的并发症，包括心脏心律失常、心脏和血管增大，甚至心源性猝死。这个项目旨在更详细地了解大脑中产生这种活动的部分。这些信息将使人们能够为高血压或心力衰竭患者开发更有选择性和更有效的治疗方法。

Increased activity from the parts of the brain which regulate blood pressure is observed in patients with cardiovascular diseases, including high blood pressure and heart failure. In some cases this increased activity might actually cause the high blood pressure. In all cases this increased activity can lead to serious complications including arrhythmias of the heart, enlargement of the heart and blood vessels, and even sudden cardiac death. This project aims to understand in more detail the parts of the brain that generate this activity. This information will enable more selective and effective treatments to be developed for people with high blood pressure or heart failure.