The significance of glial dysfunction in retinopathy of prematurity

胶质细胞功能障碍在早产儿视网膜病变中的意义

• 批准号: nhmrc : 566815
• 负责人: Prof Andrew Allen
• 金额: $ 20.78万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/significance-glial-dysfunction-retinopathy-prematurity/99392
• 关键词: significance; glial; dysfunction; retinopathy; prematurity

Abnormalities in cells at the back of the eye called photoreceptors are associated with at least 50% of all cases of blindness in this country.This project will determine whether substances released from dying photoreceptors cause the death of neighbouring cells. In addition we will examine whether treatments that block the actions of these released substances can prevent the death of photoreceptors, thereby providing a novel therapeutic agent for the treatment of devastating eye diseases.

在这个国家，至少有50%的失明病例与眼睛后部称为光感受器的细胞异常有关。这个项目将确定垂死的光感受器释放的物质是否会导致邻近细胞的死亡。此外，我们将研究阻断这些释放物质的作用的治疗是否可以防止光感受器的死亡，从而为治疗破坏性眼病提供一种新的治疗剂。