Cellular response to modulation of iron levels: studies examining ASK1, thioredoxin and ribonucleotide reductase

铁对许多重要的生物过程至关重要。最近，我证明了铁缺乏可以影响在细胞生长和死亡中起重要作用的信号通路。本研究旨在探讨目前尚不清楚的缺铁对细胞和分子的影响。我提出的研究对于理解：(1)缺铁的影响和(2)了解用于治疗各种疾病的铁螯合剂的影响至关重要。

Iron is crucial for many essential biological processes. Recently, I demonstrated that iron-depletion can affects signalling pathways that play important roles in cellular growth and death. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. My proposed research is crucial for understanding: (1) the effects of iron-deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.