Cellular response to modulation of iron levels: studies examining ASK1, thioredoxin and ribonucleotide reductase

细胞对铁水平调节的反应：检查 ASK1、硫氧还蛋白和核糖核苷酸还原酶的研究

• 批准号: nhmrc : 1035762
• 负责人: Dr Yu Yu
• 金额: $ 2.2万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cellular-response-modulation-ribonucleotide-reductase/110982
• 关键词: Cellular; response; modulation; iron; levels

Iron is crucial for many essential biological processes. Recently, I demonstrated that iron-depletion can affects signalling pathways that play important roles in cellular growth and death. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. My proposed research is crucial for understanding: (1) the effects of iron-deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.

铁对许多重要的生物过程至关重要。最近，我证明了铁缺乏会影响在细胞生长和死亡中起重要作用的信号通路。本研究旨在研究目前尚不清楚的铁缺乏的细胞和分子效应。我提出的研究对理解至关重要：（1）缺铁的影响和（2）理解用于治疗各种疾病的铁螯合剂的影响。