Central, reflex and mechanical factors in the control of human breathing muscles.

控制人体呼吸肌肉的中枢、反射和机械因素。

• 批准号: nhmrc : 1021354
• 负责人: A/Pr David Mckenzie
• 金额: $ 33.2万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/central-reflex-mechanical-breathing-muscles/110116
• 关键词: Central; reflex; mechanical; factors; control

We will study the neural output to human inspiratory muscles and how it is related to mechanical effectiveness for breathing and then how this relationship can change with respiratory disorders such as chronic obstructive pulmonary disease and obstructive sleep apnoea. We will also examine the spinal reflex connections of human breathing muscles in people with spinal cord injury. This work promises new understanding of the basic control of respiration and how it changes with disease.

我们将研究人类吸气肌的神经输出及其与呼吸机械效率的关系，以及这种关系如何随着慢性阻塞性肺病和阻塞性睡眠呼吸暂停等呼吸系统疾病而变化。我们还将检查脊髓损伤患者的人类呼吸肌的脊髓反射连接。这项工作有望对呼吸的基本控制及其如何随疾病变化产生新的认识。