Cortical, descending and reflex control of human inspiratory muscles
人体吸气肌的皮质、下降和反射控制
基本信息
- 批准号:nhmrc : 350853
- 负责人:
- 金额:$ 21.64万
- 依托单位:
- 依托单位国家:澳大利亚
- 项目类别:NHMRC Project Grants
- 财政年份:2005
- 资助国家:澳大利亚
- 起止时间:2005-01-01 至 2007-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Of all the skeletal muscles, the breathing muscles perform the most crucial action, that is, they maintain ventilation. The neural control of respiratory muscles must be finely integrated to maintain ventilation while we are awake, asleep, exercising, eating and talking. The neural circuitry for the respiratory muscles is unique. Control of respiratory muscles differs from that of limb muscles because the respiratory motoneurones are activated rhythmically but are controlled via two descending pathways. During automatic breathing, descending neural drive arises from the central respiratory pattern generator in the brainstem. Through this system, disturbances are reflexly compensated for without conscious effort. However, in addition, to automatic control, respiration can also be controlled voluntarily from the motor cortex, for example during speech or a breath hold. However, in humans the neural connections and interactions between these two centres are poorly understood. In addition to descending signals, the activity of inspiratory muscles is affected by sensory reflex inputs. The proposed studies will investigate three aspects of the control of human inspiratory muscles that act to 'pump' air into the lungs and upper airway 'dilator' muscles that act to keep the airway open. Because expiration is usually passive during quiet breathing we will focus on the neural control of inspiration. First, we will investigate some of the reflex connections of human 'pump' and 'dilator' muscles in people with and without obstructive sleep apnoea. Second, we will study the descending control of inspiratory muscles using single motor unit recordings. In addition, we will make the first detailed analysis of single motor unit activity from the tongue. This muscle critically helps preserve breathing when we sleep. Finally, we will examine the interactions between the motor cortex and medulla in the control of breathing about which relatively little is known in awake humans.
在所有骨骼肌中,呼吸肌执行最关键的动作,即维持通气。呼吸肌的神经控制必须精细整合,以在我们清醒、睡眠、锻炼、进食和说话时维持通气。呼吸肌的神经回路是独特的。呼吸肌的控制与肢体肌肉的控制不同,因为呼吸运动神经元有节奏地激活,但通过两条下行通路进行控制。在自动呼吸期间,下行神经驱动由脑干的中枢呼吸模式发生器产生。通过这个系统,干扰可以在无意识的情况下得到反射性补偿。然而,除了自动控制之外,呼吸也可以由运动皮层自主控制,例如在说话或屏气期间。然而,人类对这两个中心之间的神经联系和相互作用知之甚少。除了下降信号之外,吸气肌的活动还受到感觉反射输入的影响。拟议的研究将调查人类吸气肌(将空气“泵入”肺部)和上气道“扩张器”肌肉(保持气道开放)控制的三个方面。因为在安静呼吸期间呼气通常是被动的,所以我们将重点关注吸气的神经控制。首先,我们将研究患有或不患有阻塞性睡眠呼吸暂停的人的人体“泵”和“扩张器”肌肉的一些反射连接。其次,我们将使用单个运动单位记录来研究吸气肌的下降控制。此外,我们将对舌头的单个运动单位活动进行首次详细分析。这块肌肉对于我们睡觉时保持呼吸至关重要。最后,我们将研究运动皮层和延髓之间在控制呼吸方面的相互作用,而对于清醒的人类来说,人们对此知之甚少。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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A/Pr David Mckenzie其他文献
A/Pr David Mckenzie的其他文献
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{{ truncateString('A/Pr David Mckenzie', 18)}}的其他基金
How neural impairment affects respiratory motor function in chronic obstructive pulmonary disease and healthy ageing
神经损伤如何影响慢性阻塞性肺疾病和健康老龄化中的呼吸运动功能
- 批准号:
nhmrc : 1138920 - 财政年份:2018
- 资助金额:
$ 21.64万 - 项目类别:
Project Grants
Biomechanical, Neural and Sensory Phenotyping of the Upper Airway in Obstructive Sleep Apnoea
阻塞性睡眠呼吸暂停上呼吸道的生物力学、神经和感觉表型
- 批准号:
nhmrc : 1058974 - 财政年份:2014
- 资助金额:
$ 21.64万 - 项目类别:
Project Grants
Novel therapeutic phenotyping for sleep apnoea - A paradoxical role for sedatives
睡眠呼吸暂停的新治疗表型——镇静剂的矛盾作用
- 批准号:
nhmrc : 1042493 - 财政年份:2013
- 资助金额:
$ 21.64万 - 项目类别:
Project Grants
Central, reflex and mechanical factors in the control of human breathing muscles.
控制人体呼吸肌肉的中枢、反射和机械因素。
- 批准号:
nhmrc : 1021354 - 财政年份:2012
- 资助金额:
$ 21.64万 - 项目类别:
Project Grants
Control of human inspiratory muscles in health and disease
健康和疾病中人体呼吸肌的控制
- 批准号:
nhmrc : 568701 - 财政年份:2009
- 资助金额:
$ 21.64万 - 项目类别:
NHMRC Project Grants
Novel neuromechanical measurements of the human upper airway in health and disease
健康和疾病状态下人类上呼吸道的新型神经力学测量
- 批准号:
nhmrc : 455228 - 财政年份:2007
- 资助金额:
$ 21.64万 - 项目类别:
NHMRC Project Grants
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