Novel therapeutic phenotyping for sleep apnoea - A paradoxical role for sedatives

睡眠呼吸暂停的新治疗表型——镇静剂的矛盾作用

• 批准号: nhmrc : 1042493
• 负责人: A/Pr David Mckenzie
• 金额: $ 42.62万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-therapeutic-phenotyping-role-sedatives/111476
• 关键词: Novel; therapeutic; phenotyping; sleep; apnoea

Sleeping pill (sedative) use has risen dramatically. Sedatives may worsen a common breathing condition called obstructive sleep apnoea (OSA). Accordingly, their use has been discouraged in OSA. However, recent studies indicate that certain sedatives may actually reduce OSA severity in some patients. By studying the effects of common sedatives on OSA and breathing, this proposal aims to explain these apparent paradoxical responses and ultimately provide a new treatment approach for OSA.

安眠药（镇静剂）的使用急剧增加。镇静剂可能会加重一种常见的呼吸状况，称为阻塞性睡眠呼吸暂停（OSA）。因此，在OSA中不鼓励使用它们。然而，最近的研究表明，某些镇静剂实际上可以降低某些患者的OSA严重程度。通过研究常用镇静剂对阻塞性睡眠呼吸暂停和呼吸的影响，旨在解释这些明显的矛盾反应，并最终为阻塞性睡眠呼吸暂停提供一种新的治疗方法。