Characterization of the novel drug and xenobiotic metabolizing UGT3A enzyme family

消除体内或环境来源的化学物质对于保持身体健康和预防使人衰弱的疾病至关重要。我们发现了两种酶，它们利用葡萄糖和其他糖来解毒脂溶性化学物质。在这个项目中，我们将研究这些酶是如何工作的，以及它们在体内是如何被调节的。有了这些知识，我们也许能够针对药物和化学解毒的过程，使它们更有效。

The elimination of chemicals made in the body or from environmental sources is essential for the maintenance of good health and the prevention of debilitating diseases. We have discovered two enzymes that use glucose and other sugars to detoxify fat-soluble chemicals. In this project we will study how these enzymes work and how they are regulated in the body. With this knowledge, we may be able to target the processes of drug and chemical detoxification to make them more efficient.