Early transition metal and lanthanide amidate complexes: modular, easily accessed complexes for catalysis

早期过渡金属和镧系酰胺配合物：模块化、易于获取的催化配合物

• 批准号: 240749-2007
• 负责人: Schafer, Laurel
• 金额: $ 3.57万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=361977
• 关键词: Early; transition; metal; lanthanide; amidate

Early transition metals, such as titanium and zirconium, and lanthanide metals have been used successfully for metal-mediated organic synthesis.  As catalysts, these metals are able to promote reactions that normally cannot occur.  Catalysis is very important for industrial applications, as it promotes chemical tranformations in a cost effective, energy efficient manner while minimizing chemical waste.  Certainly catalysis is key to the development of environmentally friendly green chemistry and sustainable methods for chemical production.  Early transition and lanthanide metals are particularly attractive for large scale applications, due to the fact that they are of low cost and low toxicity.  The easily prepared, inexpensive catalytic complexes developed in our research group show promise for a broad range of important catalytic transformations in the pharmaceutical, polymer and fine chemical industries.  Using the class of metals presented above, we have developed a family of complexes (amidate complexes) that display unprecedented and highly desirable catalytic activity in selective C-N bond formation for intramolecular reactions (both reactive partners are contained in one starting material).  We propose to continue our exploration of these complexes for C-N bond formation, to achieve a long-standing goal in chemical synthesis, the addition of amines (N-H bonds) to simple alkenes (C=C bonds) in an intermolecular fashion (reactive partners are two separate molecules).    In addition to selective C-N bond formation we will be exploring the potential application of this new family of complexes in C-C coupling reactions, as well as polymerization reactions.  Recent results demonstrate the usefulness of these complexes in the catalytic preparation of biodegradable, compostable polymers.The funds requested will support our on-going efforts to fully explore and develop these new catalytic systems.

早期的过渡金属，如钛和锆，以及镧系金属已经成功地用于金属介导的有机合成。作为催化剂，这些金属能够促进通常不能发生的反应。催化在工业应用中非常重要，因为它以成本有效的方式促进化学转化，催化是发展环境友好的绿色化学和可持续的化学生产方法的关键。早过渡金属和镧系金属是由于它们具有低成本和低毒性的事实，对于大规模应用特别有吸引力。我们研究小组开发的易于制备、廉价的催化络合物显示出在制药、聚合物和精细化学工业中广泛的重要催化转化的前景。使用上述金属类别，我们发展出了一系列的复合物（酰胺化物络合物）在分子内反应的选择性C-N键形成中显示出前所未有的和高度期望的催化活性（两种反应性伴侣都包含在一种起始材料中）。我们建议继续探索这些络合物的C-N键形成，为了实现化学合成中的一个长期目标，将胺（N-H键）以分子间的方式加成到简单的烯烃（C=C键）上（反应伙伴是两个独立的分子）。 除了选择性的C-N键形成外，我们还将探索这类新的配合物在C-C偶联反应和聚合反应中的潜在应用。最近的研究结果表明，这些配合物在催化制备可生物降解、可堆肥的聚合物中是有用的。所申请的资金将支持我们正在进行的努力，以充分探索和开发这些新的催化体系。