Multifunctional biocoatings for orthopaedic and dental implants

用于骨科和牙科植入物的多功能生物涂层

• 批准号: 249524-2006
• 负责人: Wang, Rizhi
• 金额: $ 2.08万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=362757
• 关键词: Multifunctional; biocoatings; orthopaedic; dental; implants

Joint replacement and dental implants represent the successful applications of synthetic materials in the treatment of diseases and the restoration of tissue functions. Some of the remaining issues include possible infection, slow bone healing process, and early implant loosening. With the steady increase in the number of joint replacements performed (nearly 50,000 hospitalizations for hip and knee replacements in 2002-2003 in Canada), there is an urgent need for novel orthopaedic and dental implants that can integrate with bone earlier and last longer.    To meet the challenges, this biomaterials research proposal will be focused on the development of multifunctional biocoatings. A multifunctional biocoating is a coating that possesses high biological functions (bioactivity), pharmacological functions (anti-infection, anti-osteolysis), as well as mechanical functions (robust). The idea is to apply the multifunctional biocoatings to orthopaedic and dental implants to achieve both early implant fixation and longevity. Research projects will be established to address key issues in multifunctional biocoatings, from the processing of novel bioactive coatings, surface design, drug delivery, to coating integrity. Significant progress is expected in the following directions: the design, processing and quality control of bioactive coatings; the interaction with drugs (antibiotics, bisphosphonates); and the development of clinically relevant testing standards. The research program will have significant contributions to the development of new generation of orthopaedic implants, to the health care, and to the training of students.

关节置换和牙科植入物代表了合成材料在治疗疾病和恢复组织功能方面的成功应用。一些剩余的问题包括可能的感染、骨愈合过程缓慢和早期植入物松动。随着关节置换手术数量的稳步增加（2002-2003年加拿大有近50，000例髋关节和膝关节置换住院），迫切需要能够更早与骨结合并持续更长时间的新型矫形和牙科植入物。 为迎接挑战，本课题的研究重点将放在多功能生物涂层的开发上。多功能生物涂层是一种具有高生物学功能（生物活性）、药理学功能（抗感染、抗骨质溶解）以及机械功能（坚固）的涂层。我们的想法是将多功能生物涂层应用于骨科和牙科种植体，以实现早期种植体固定和寿命。将建立研究项目，以解决多功能生物涂层的关键问题，从新型生物活性涂层的加工，表面设计，药物输送，涂层的完整性。预计在以下方面将取得重大进展：生物活性涂层的设计、加工和质量控制;与药物（抗生素、双膦酸盐）的相互作用;以及制定临床相关的测试标准。该研究计划将对新一代骨科植入物的开发，医疗保健和学生培训做出重大贡献。