Multifunctional biocoatings for orthopaedic and dental implants

关节置换和牙科植入物代表了合成材料在治疗疾病和恢复组织功能方面的成功应用。剩下的一些问题包括可能的感染，缓慢的骨愈合过程，以及种植体早期松动。随着关节置换手术数量的稳步增加(2002-2003年加拿大有近5万人因髋关节和膝关节置换而住院)，迫切需要能够更早与骨骼结合、寿命更长的新型骨科和牙科植入物。为了迎接挑战，这份生物材料研究提案将重点放在多功能生物涂料的发展上。多功能生物涂层是一种具有高生物学功能(生物活性)、药理功能(抗感染、抗骨溶解)以及机械功能(坚固)的涂层。其想法是将多功能生物涂料应用于骨科和牙科植入物，以实现植入物的早期固定和寿命。将建立研究项目，以解决多功能生物涂层中的关键问题，从新型生物活性涂层的加工、表面设计、药物输送到涂层完整性。预计将在以下方面取得重大进展：生物活性涂层的设计、加工和质量控制；与药物(抗生素、双磷酸盐)的相互作用；以及临床相关测试标准的制定。该研究项目将对新一代骨科植入物的开发、医疗保健和学生的培训做出重大贡献。

Joint replacement and dental implants represent the successful applications of synthetic materials in the treatment of diseases and the restoration of tissue functions. Some of the remaining issues include possible infection, slow bone healing process, and early implant loosening. With the steady increase in the number of joint replacements performed (nearly 50,000 hospitalizations for hip and knee replacements in 2002-2003 in Canada), there is an urgent need for novel orthopaedic and dental implants that can integrate with bone earlier and last longer.    To meet the challenges, this biomaterials research proposal will be focused on the development of multifunctional biocoatings. A multifunctional biocoating is a coating that possesses high biological functions (bioactivity), pharmacological functions (anti-infection, anti-osteolysis), as well as mechanical functions (robust). The idea is to apply the multifunctional biocoatings to orthopaedic and dental implants to achieve both early implant fixation and longevity. Research projects will be established to address key issues in multifunctional biocoatings, from the processing of novel bioactive coatings, surface design, drug delivery, to coating integrity. Significant progress is expected in the following directions: the design, processing and quality control of bioactive coatings; the interaction with drugs (antibiotics, bisphosphonates); and the development of clinically relevant testing standards. The research program will have significant contributions to the development of new generation of orthopaedic implants, to the health care, and to the training of students.