The Regulation of Antibody: A Systems Approach

抗体由b细胞产生，对免疫系统的功能至关重要。B细胞在体内循环，当它们遇到入侵者时，它们会成熟为产生抗体的细胞（ASC）。如果将来发生同样的感染，一小部分细胞成为“记忆”细胞，有可能成为ASC。这是疫苗接种的基础。该项目旨在了解B细胞如何转变为ASC。我们的最终目标是能够改进疫苗，了解过敏、狼疮、关节炎和白血病等疾病，以开发新的治疗方法。

Antibodies are made by B-cells and are essential for a functional immune system. B cells circulate in the body, and, when they encounter an invader, they mature into antibody-producing cells (ASC). A small proportion of the cells become “memory” cells with the potential to become ASC should the same infection occur in the future. This is the basis of vaccination. This program aims to understand how a B cell changes into an ASC. We aim eventually to be able to improve vaccines and understand diseases such as allergy, lupus, arthritis and leukaemia to develop novel therapies.