The Regulation of Antibody: A Systems Approach

抗体的调节：系统方法

• 批准号: nhmrc : 575500
• 负责人: Prof David Tarlinton
• 金额: $ 540.86万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Programs
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-antibody-systems-approach/101132
• 关键词: Regulation; Antibody; Systems; Approach

Antibodies are made by B-cells and are essential for a functional immune system. B cells circulate in the body, and, when they encounter an invader, they mature into antibody-producing cells (ASC). A small proportion of the cells become “memory” cells with the potential to become ASC should the same infection occur in the future. This is the basis of vaccination. This program aims to understand how a B cell changes into an ASC. We aim eventually to be able to improve vaccines and understand diseases such as allergy, lupus, arthritis and leukaemia to develop novel therapies.

抗体由B细胞产生，对功能性免疫系统至关重要。B细胞在体内循环，当它们遇到入侵者时，它们成熟为抗体产生细胞（ASC）。一小部分细胞成为“记忆”细胞，如果将来发生相同的感染，则有可能成为ASC。这是接种疫苗的基础。该计划旨在了解B细胞如何转变为ASC。我们的目标是最终能够改进疫苗，了解过敏、狼疮、关节炎和白血病等疾病，以开发新的疗法。