A Systems Approach to the Adaptive Immune Response

适应性免疫反应的系统方法

• 批准号: nhmrc : 1054925
• 负责人: Prof David Tarlinton
• 金额: $ 631.79万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Program Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/systems-approach-adaptive-immune-response/112422
• 关键词: Systems; Approach; Adaptive; Immune; Response

The lymphocyte plays a vital role in our immune defence. When lymphocytes encounter a foreign invader, such as a virus, they make a series of decisions that influence the strength, type, and longevity of the immunity created. This program aims to understand how lymphocytes make decisions at the molecular level that affect cell and whole of system level behaviour. We aim to improve vaccines and understand diseases such as allergy, lupus, arthritis and leukaemia to develop novel therapies.

淋巴细胞在我们的免疫防御中起着至关重要的作用。当淋巴细胞遇到外来入侵者时，如病毒，它们会做出一系列决定，影响所产生的免疫力的强度，类型和寿命。该计划旨在了解淋巴细胞如何在分子水平上做出影响细胞和整个系统水平行为的决定。我们的目标是改进疫苗，了解过敏、狼疮、关节炎和白血病等疾病，以开发新的疗法。