The regulation of antibody: A systems approach

抗体的调节：系统方法

• 批准号: nhmrc : 356202
• 负责人: Prof David Tarlinton
• 金额: $ 291.89万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Programs
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-antibody-systems-approach/76019
• 关键词: regulation; antibody; systems; approach

This program brings together a team of researchers from The Walter and Eliza Hall Institute of Medical Research to study how the body regulates antibody production to fight disease. Antibodies are made by B-cells and are essential for a functional immune system. B cells circulate in the body, searching for signs of infection. When they encounter an invader, they mature, with the help of other immune cells, into antibody-producing cells. A small proportion of the cells are set aside as _memory� cells that can rapidly become antibodyproducing cells should the same infection occur again in the future. This is the basis of vaccination. This program aims to understand how a B cell changes into an antibody-producing cell, by studying the genes that are known to be required for the cells to form, or to do their work. We will study animals whose immune systems are under- or over-active, to find out what part of the antibody-producing process is faulty. Using this information, we hope eventually to be able to study diseases of antibody producing cells in humans (as occur in allergy, asthma, rheumatoid arthritis and leukaemia), to be able to identify the precise cause of the problem, and to suggest a therapy. This information may also be used to improve the outcome of vaccination where an enhanced antibody response is desired.

该项目汇集了来自沃尔特和伊丽莎霍尔医学研究所的一组研究人员，研究身体如何调节抗体产生以对抗疾病。抗体由B细胞产生，对功能性免疫系统至关重要。B细胞在体内循环，寻找感染的迹象。当它们遇到入侵者时，它们在其他免疫细胞的帮助下成熟为产生抗体的细胞。一小部分细胞被留作记忆细胞，如果将来再次发生同样的感染，这些细胞可以迅速成为抗体产生细胞。这是接种疫苗的基础。该计划旨在了解B细胞如何转变为抗体产生细胞，通过研究已知细胞形成或完成其工作所需的基因。我们将研究免疫系统不活跃或过度活跃的动物，以找出抗体产生过程的哪一部分有缺陷。利用这些信息，我们希望最终能够研究人类抗体产生细胞的疾病（如过敏，哮喘，类风湿性关节炎和白血病），能够确定问题的确切原因，并提出治疗方法。该信息也可用于改善疫苗接种的结果，其中需要增强的抗体应答。