The regulation of B cell differentiation and survival in response to antigen challenge

响应抗原攻击而调节 B 细胞分化和存活

• 批准号: nhmrc : 1060675
• 负责人: Prof David Tarlinton
• 金额: $ 50.9万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-b-cell-antigen-challenge/454846
• 关键词: regulation; cell; differentiation; survival; response

Antibodies are crucial to health and well being but can cause disease if their production is not controlled appropriately. This research program examines the basis of antibody production in normal situations and in situations where it is causing illness, in diseases like system lupus erythematosus (SLE) and in cancers of antibody producing cells called multiple myeloma (MM). The aim is to enable control of the process to achieve better health outcomes and better management of disease.

抗体对健康和福祉至关重要，但如果其生产得不到适当控制，则可能导致疾病。该研究项目检查了正常情况下抗体产生的基础，以及在引起疾病的情况下，如系统性红斑狼疮（SLE）和称为多发性骨髓瘤（MM）的抗体产生细胞的癌症。其目的是能够控制这一过程，以实现更好的健康成果和更好的疾病管理。