Mass spectrometer for the radiation sciences

核医学与放射生物学系是一个多学科小组，研究辐射诱导DNA损伤的机制，低能电子和动力学热离子的物理化学。同样重要的是，该小组致力于开发和应用新的成像剂，用于正电子发射断层扫描（PET）和磁共振成像（MRI）。我们的团队需要一台质谱仪来识别和量化几种类型的研究中的产物，包括：DNA损伤，凝聚表面研究和有机合成。对于某些实验，我们必须检测到相对少量的产物，这些产物是由修饰的寡核苷酸的光解或分子薄膜轰击凝聚表面产生的。目前，产物通过液相色谱法和紫外检测进行检测;然而，这种方法不能提供重要的结构信息。除了上述研究外，我们的小组还进行了广泛的有机合成，特别是用于PET和MRI的修饰寡肽。为了优化化学反应，我们需要通过质谱监测中间体、产物和副反应的形成。购买质谱仪是必要的，以培养高素质的人才，并继续我们在辐射科学的研究计划。

The department of Nuclear Medicine and Radiobiology is a multidisciplinary group which studies the mechanism of radiation induced DNA damage, the physical chemistry of low energy electrons and kinetically hot ions. Equally important, this group works on the development and application of novel imaging agents for positron emission tomography (PET) and magnetic resonance imaging (MRI). Our group needs a mass spectrometer to identify and quantify products in several types of studies including: DNA damage, condensed surface studies, and organic synthesis. For certain experiments, we must detect relatively small amounts of products generated by the photolysis of modified oligonucleotides or the bombardment of thin films of molecules on condensed surfaces. Presently, the products are detected by liquid chromatography with UV detection; however, this method does not give us important structural information. In addition to the above studies, our group does extensive organic synthesis particularly of modified oligopeptides for PET and MRI. To optimize the chemical reactions, we need to monitor the formation of intermediates, products and side-reactions by mass spectrometry. The purchase of a mass spectrometer is necessary to train highly qualified personnel and pursue our research programs in the radiation sciences.