Regulation of HIV-1 Tat Trafficking in cells

HIV-1 Tat 在细胞内运输的调控

• 批准号: nhmrc : 552419
• 负责人: A/Pr David Harrich
• 金额: $ 32.97万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-hiv-1-trafficking-cells/95781
• 关键词: Regulation; HIV; Tat; Trafficking; cells

AIDS is caused by the human immunodeficiency virus type 1 (HIV-1). Long-term HIV infection leads to increased incidence of Kaposi's sarcoma, AIDS dementia complex, and immune dysfunctions. The HIV-1 Tat protein has been linked to disease progression. However, Tat is predominantly found in the cell nucleus while measurable levels in patient serum. This is not believed to be a passive event caused by dying cells. Here we will investigate how Tat is released by HIV-1 infected cells.

艾滋病是由人类免疫缺陷病毒1型（HIV-1）引起的。长期HIV感染导致卡波西肉瘤、艾滋病痴呆综合征和免疫功能障碍的发病率增加。HIV-1达特蛋白与疾病进展有关。然而，达特主要存在于细胞核中，而在患者血清中可测量水平。这不被认为是由死亡细胞引起的被动事件。在这里，我们将调查如何达特是由HIV-1感染的细胞释放。