How Does A Host Cell Stimulatory Factor Stabilize The HIV-1 Reverse Transcription Complex?

宿主细胞刺激因子如何稳定 HIV-1 逆转录复合物？

• 批准号: nhmrc : 1002440
• 负责人: A/Pr David Harrich
• 金额: $ 42.13万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/does-host-cell-transcription-complex/108812
• 关键词: How; Does; Host; Cell; Stimulatory

We have identified a host cell activity which HIV uses to infect cells. The activity assists the uniques ability of HIV to convert its genome to a form which inserts itself into the host cell DNA. If we can identify the protein responsible for this activity we may be able to target it for drug development. Targetting host cell proteins rather than virus proteins for new drug may have advantages in preventing the acquisition of drug resistance.

我们已经确定了HIV用来感染细胞的一种宿主细胞活动。这一活动有助于艾滋病毒独特的能力，将其基因组转换为一种将自己插入宿主细胞DNA的形式。如果我们能确定负责这一活动的蛋白质，我们就可能将其作为药物开发的靶点。针对宿主细胞蛋白质而不是病毒蛋白质作为新药的靶点，可能在防止获得耐药性方面具有优势。