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How Does A Host Cell Stimulatory Factor Stabilize The HIV-1 Reverse Transcription Complex?

How Does A Host Cell Stimulatory Factor Stabilize The HIV-1 Reverse Transcription Complex?
宿主细胞刺激因子如何稳定 HIV-1 逆转录复合物?
批准号:
nhmrc : 1002440
负责人:
A/Pr David Harrich
金额:
$42.13万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31

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中文摘要
翻译
我们已经确定了HIV用来感染细胞的宿主细胞活性。这种活性有助于艾滋病毒将其基因组转化为插入宿主细胞DNA的形式的独特能力。如果我们能够鉴定出负责这种活性的蛋白质,我们就可以将其作为药物开发的目标。靶向宿主细胞蛋白而不是病毒蛋白的新药可能在防止获得耐药性方面具有优势。
英文摘要
We have identified a host cell activity which HIV uses to infect cells. The activity assists the uniques ability of HIV to convert its genome to a form which inserts itself into the host cell DNA. If we can identify the protein responsible for this activity we may be able to target it for drug development. Targetting host cell proteins rather than virus proteins for new drug may have advantages in preventing the acquisition of drug resistance.
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A potent anti-HIV-1 gene therapy agent in a humanised mouse model
A potent anti-HIV-1 gene therapy agent in a humanised mouse model
  • 批准号:
    nhmrc : GNT1085359
  • 项目类别:
    Project Grants
  • 资助金额:
    $110.11万
  • 财政年份:
    2015
  • 负责人:
    A/Pr David Harrich
  • 依托单位:
eEF1A1 is critical for HIV-1 reverse transcription and replication
The Human Eukaryotic Translation Elongation Factor 1A is a Paramyxovirus Virus Dependency Factor
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