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How Does A Host Cell Stimulatory Factor Stabilize The HIV-1 Reverse Transcription Complex?

How Does A Host Cell Stimulatory Factor Stabilize The HIV-1 Reverse Transcription Complex?
宿主细胞刺激因子如何稳定 HIV-1 逆转录复合物？
批准号：
nhmrc : 1002440
负责人：
A/Pr David Harrich
金额：
$42.13万
依托单位：
Queensland Institute of Medical Research
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2011
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2011-01-01 至 2013-12-31
来源：
https://researchdata.edu.au/does-host-cell-transcription-complex/108812
关键词：
HowDoesHostCellStimulatory

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英文摘要
We have identified a host cell activity which HIV uses to infect cells. The activity assists the uniques ability of HIV to convert its genome to a form which inserts itself into the host cell DNA. If we can identify the protein responsible for this activity we may be able to target it for drug development. Targetting host cell proteins rather than virus proteins for new drug may have advantages in preventing the acquisition of drug resistance.
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A potent anti-HIV-1 gene therapy agent in a humanised mouse model
  • 批准号：
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  • 项目类别：
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  • 资助金额：
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  • 财政年份：
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