HOST CELL FACTORS INCREASE THE EFFICIENCY OF HIV-1 REVERSE TRANSCRIPTION

宿主细胞因子提高 HIV-1 逆转录效率

• 批准号: nhmrc : 496663
• 负责人: A/Pr David Harrich
• 金额: $ 42.47万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/host-cell-factors-reverse-transcription/77165
• 关键词: HOST; CELL; FACTORS; INCREASE; EFFICIENCY

We have found that when human immunodeficiency virus (HIV) infects a cell, it uses functions of the host to better infect. At this point, we do not know the identity of the host cell factors involved. If we are able to identify the factors we might be able to specifically target them without affecting normal cell functions. This approach has the advantage that it minimises the opportunities for the virus to develop drug resitance, which is increasingly a problem with HIV.

我们发现，当人类免疫缺陷病毒（HIV）感染细胞时，它会利用宿主的功能更好地感染。在这一点上，我们不知道的身份的宿主细胞因子参与。如果我们能够识别这些因素，我们就可以在不影响正常细胞功能的情况下特异性地靶向它们。这种方法的优点是，它最大限度地减少了病毒产生耐药性的机会，这越来越成为艾滋病毒的一个问题。