An RNA Element Negatively Regulates Initation HIV-1 Reverse transcription and Inhibits Proviral Integration

RNA 元件负调控 HIV-1 逆转录起始并抑制原病毒整合

• 批准号: nhmrc : 1004715
• 负责人: A/Pr David Harrich
• 金额: $ 38.78万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-rna-element-proviral-integration/109064
• 关键词: RNA; Element; Negatively; Regulates; Initation

We recently made the discovery that the virus that causes AIDS can be potently inhibited by stimulating a specific step in the virus life cycle. Our evidence suggests this stimulation is controlled by a host factor which will be identified in this study. Its discovery would be an important step towards a new means to fight HIV infection.

我们最近发现，通过刺激病毒生命周期中的一个特定步骤，可以有效地抑制引起艾滋病的病毒。我们的证据表明，这种刺激是由宿主因素控制的，这将在本研究中确定。它的发现将是对抗艾滋病毒感染的新手段的重要一步。