The regulation of IgE antibody production by antigen-specific B cells

抗原特异性 B 细胞对 IgE 抗体产生的调节

• 批准号: nhmrc : 1044477
• 负责人: Dr Cindy Ma
• 金额: $ 30.28万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-ige-antibody-b-cells/111667
• 关键词: regulation; IgE; antibody; production; antigen

Asthma and other allergies are caused by the inappropriate production of IgE antibodies by the immune system. IgE is not produced in response to most infections but the controls that normally prevent IgE production are unknown. We have identified two separate molecules that prevent IgE production during immune responses. In this proposal we aim to investigate how these controls work. This information may help to devise strategies for controlling IgE production and therefore allergic disease.

哮喘和其他过敏是由免疫系统产生不适当的IgE抗体引起的。大多数感染不会产生IgE，但通常阻止IgE产生的控制机制尚不清楚。我们已经确定了两种不同的分子在免疫反应中阻止IgE的产生。在这个提议中，我们的目标是研究这些控制是如何工作的。这些信息可能有助于制定控制IgE产生的策略，从而控制过敏性疾病。