Utilising human primary immunodeficiencies to study lymphocyte differentiation

利用人类原发性免疫缺陷研究淋巴细胞分化

• 批准号: nhmrc : 1008820
• 负责人: Dr Cindy Ma
• 金额: $ 28.63万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/utilising-human-primary-lymphocyte-differentiation/109344
• 关键词: Utilising; human; primary; immunodeficiencies; study

Human immunodeficiencies are diseases arising from naturally occurring mutations. In this instance, the specific genes mutated in the immunodeficiencies we study have been identified. However, it is unclear how defects in these genes make an individual manifest as an immune deficient state, rendering them vulnerable to disease. By studying immune cells from these individuals we hope to uncover the normal function of these genes and subsequently provide for new therapies for these conditions.

人类免疫缺陷是由自然发生的突变引起的疾病。在这种情况下，在我们研究的免疫缺陷中突变的特定基因已经被识别出来。然而，目前尚不清楚这些基因的缺陷是如何使个体表现为免疫缺陷状态，从而使他们容易感染疾病。通过研究这些个体的免疫细胞，我们希望发现这些基因的正常功能，并随后为这些疾病提供新的治疗方法。