REGULATION OF HUMORAL IMMUNITY BY PI3K p110?

PI3K p110 调节体液免疫？

• 批准号: nhmrc : 1088215
• 负责人: Dr Cindy Ma
• 金额: $ 31.53万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-humoral-immunity-pi3k-p110/519199
• 关键词: REGULATION; HUMORAL; IMMUNITY; PI3K; p110

The immune system usually rapidly responds to eradicate infectious pathogens. However patients with mutations in the gene PI3KCD, which is important for delivering messages within immune cells, are unable to control infections with some bacteria and viruses. We will study the effects of these mutations on B cells, the immune cells produce antibodies that bind to and remove pathogens from our body. This will explain some of the clinical features of this disease and reveal potential new treatments

免疫系统通常迅速响应以根除传染性病原体。然而，PI3KCD基因突变的患者，这对在免疫细胞内传递信息很重要，无法控制某些细菌和病毒的感染。我们将研究这些突变对B细胞的影响，免疫细胞产生抗体，结合并清除我们体内的病原体。这将解释这种疾病的一些临床特征，并揭示潜在的新治疗方法