Regulation of immune responses by STAT1 and STAT3

STAT1 和 STAT3 对免疫反应的调节

• 批准号: nhmrc : GNT1139663
• 负责人: Dr Cindy Ma
• 金额: $ 70.44万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-immune-responses-stat1-stat3/1348246
• 关键词: Regulation; immune; responses; STAT1; STAT3

The immune system must be tightly regulated to make sure that it makes the right response to effectively fight off infection whilst avoiding inappropriate responses that cause damage such as in autoimmunity, inflammation or allergy. This project studies patients who have genetic defects that affect their immune systems and make them susceptible to infection and/or harmful immune responses. This will reveal some of the critical signals that maintain immune control.

免疫系统必须受到严格的调节，以确保它做出正确的反应，以有效地抵抗感染，同时避免导致损伤的不适当反应，如自身免疫，炎症或过敏。该项目研究具有遗传缺陷的患者，这些遗传缺陷影响他们的免疫系统，使他们容易受到感染和/或有害的免疫反应。这将揭示一些维持免疫控制的关键信号。