Mechanisms that control Epstein Barr Virus infection and their dysregulation in X-linked lymphoproliferative disease

控制 Epstein Barr 病毒感染的机制及其在 X 连锁淋巴增殖性疾病中的失调

• 批准号: nhmrc : 1050471
• 负责人: Dr Cindy Ma
• 金额: $ 30.27万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-control-epstein-lymphoproliferative-disease/112156
• 关键词: Mechanisms; control; Epstein; Barr; Virus

EBV is ubiquitous virus that infects more than 90% of the population worldwide. Although infection is largely asymptomatic in most healthy individuals, EBV is nonetheless associated with the development of at least 7 distinct types of human malignancies. Most importantly, EBV is still a huge healthy problem in conditions of immune suppression. Therefore a better understanding of the mechanisms involved in effective control of the virus will help develop better immune therapies and vaccines.

EBV是一种普遍存在的病毒，感染了全球90%以上的人口。尽管大多数健康个体的感染基本上没有症状，但EB病毒与至少7种不同类型的人类恶性肿瘤的发生有关。最重要的是，在免疫抑制的情况下，EBV仍然是一个巨大的健康问题。因此，更好地了解有效控制病毒的机制将有助于开发更好的免疫疗法和疫苗。