The role of PLZF in regulating the antiviral activity of interferons

PLZF在调节干扰素抗病毒活性中的作用

• 批准号: nhmrc : 606425
• 负责人: Dr Dakang Xu
• 金额: $ 43.48万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-plzf-regulating-activity-interferons/99513
• 关键词: role; PLZF; regulating; antiviral; activity

Interferons are the first line of defence against viral infection. We have shown that the transcription factor promyelocytic leukemia zinc finger protein (PLZF) is a novel regulator of the interferon response. Thus we hypothesize that PLZF is a critical component of the host's innate immune system. This study will provide new insights into the understanding of signal transduction mechanisms, as well as improve our ability to modulate sensitivity to interferon to protect against viral diseases.

干扰素是抵御病毒感染的第一道防线。我们已经证明转录因子早幼粒细胞白血病锌指蛋白（PLZF）是干扰素反应的一种新的调节因子。因此，我们假设PLZF是宿主先天免疫系统的关键组成部分。这项研究将为理解信号转导机制提供新的见解，并提高我们调节对干扰素的敏感性以预防病毒性疾病的能力。