Regulation Of Macrophage Function And Gene Expression By The Th2-Promoting Stimulus, ES-62

Th2 促进刺激对巨噬细胞功能和基因表达的调节，ES-62

• 批准号: nhmrc : 301210
• 负责人: Prof David Hume
• 金额: $ 31.06万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-macrophage-function-es-62/82872
• 关键词: Regulation; Macrophage; Function; Gene; Expression

White blood cells are responsible for co-ordinating the immune response against foreign micro-organisms. Macrophages are a particular type of white blood cell that attempt to destroy microbes during the initial stages of an infection, but also release toxic substances that are responsible for pathology and side effects during many immune responses. This project aims to address how macrophages are involved in a particular type of immune response that develops when individuals are susceptible to certain diseases including asthma and diseases associated with intracellular infections. We are identifying genes expressed in macrophages during these immune responses that are likely to be involved in susceptibility to such diseases.

白细胞负责协调对抗外来微生物的免疫反应。巨噬细胞是一种特殊类型的白细胞，在感染的初始阶段试图摧毁微生物，但也会释放有毒物质，在许多免疫反应中导致病理和副作用。该项目旨在解决巨噬细胞如何参与特定类型的免疫反应，当个体易患某些疾病时，包括哮喘和与细胞内感染相关的疾病。我们正在鉴定巨噬细胞在这些免疫反应中表达的基因，这些基因可能与这些疾病的易感性有关。