Macrophage control of mammalian growth and development

巨噬细胞控制哺乳动物生长发育

• 批准号: DP210102998
• 负责人: Prof David Hume
• 金额: $ 39.72万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-07-19 至 2024-07-18
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102998
• 关键词: Macrophage; control; mammalian; growth; development

The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new knowledge that will challenge current concepts of mammalian growth control. The outcomes will enhance Australia's international reputation in the fields of physiology, immunology and developmental biology.

哺乳动物出生后的即刻阶段对生存、长期健康和生产力至关重要。该项目是一个国际合作项目，旨在研究被称为巨噬细胞的先天免疫系统细胞如何在出生后早期控制躯体生长和成熟器官功能的发育。该项目旨在投资于新的动物模型和一项新的发现，以产生将挑战当前哺乳动物生长控制概念的重要新知识。这一结果将提高澳大利亚在生理学、免疫学和发育生物学领域的国际声誉。