Reversal of diabetes in pigs using liver-directed gene therapy

使用肝脏定向基因疗法逆转猪的糖尿病

• 批准号: nhmrc : 513100
• 负责人: A/Pr Bronwyn O'Brien
• 金额: $ 38.26万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/reversal-diabetes-pigs-gene-therapy/78418
• 关键词: Reversal; diabetes; pigs; using; liver

Type I diabetes mellitus is caused by the autoimmune destruction of the beta cells of the pancreas that secrete insulin. We have shown that we can cure diabetes in spontaneously diabetic mice by delivery of the insulin gene to the liver using a non-pathogenic viral delivery system. The study aims to repeat this work in pigs which have similar physiology to humans. If successful this would be proof-of-principle that we could theoretically control blood glucose levels in humans.

1型糖尿病是由分泌胰岛素的胰腺β细胞的自身免疫性破坏引起的。我们已经证明，我们可以通过使用非致病性病毒递送系统将胰岛素基因递送到肝脏来治愈自发性糖尿病小鼠的糖尿病。这项研究的目的是在与人类生理学相似的猪身上重复这项工作。如果成功的话，这将是我们理论上可以控制人类血糖水平的原理证明。