The role of apoptotic caspases in regulating type I interferon production

凋亡半胱天冬酶在调节 I 型干扰素产生中的作用

• 批准号: nhmrc : GNT1077750
• 负责人: Prof Benjamin Kile
• 金额: $ 76.15万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-apoptotic-caspases-interferon-production/1345163
• 关键词: role; apoptotic; caspases; regulating; type

Type I interferons (IFNs) are potent anti-viral cytokines. Dysregulated type I IFN responses result in major pathologies, e.g., embryonic lethality and defects in tissue homeostasis. We have identified a novel molecular mechanism regulating IFN production that relies on the host’s own apoptotic caspases. We hypothesize that apoptotic caspases critically regulate IFN responses during the process of cell death, with implications for tissue homeostasis and host responses to infection.

I型干扰素（IFN）是有效的抗病毒细胞因子。失调的I型IFN应答导致主要病理，例如，胚胎死亡和组织内稳态缺陷。我们已经确定了一种新的分子机制，调节IFN的生产，依赖于宿主自身的凋亡半胱天冬酶。我们假设凋亡半胱天冬酶在细胞死亡过程中严格调节IFN反应，影响组织稳态和宿主对感染的反应。