Elucidating the mechanisms of mitochondrial DNA escape

阐明线粒体 DNA 逃逸机制

• 批准号: DP200103637
• 负责人: Prof Benjamin Kile
• 金额: $ 37.21万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-12-31 至 2025-06-20
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200103637
• 关键词: Elucidating; mechanisms; mitochondrial; DNA; escape

The human body is powered by mitochondria, microscopic components of living cells that make the energy they need to function. Mitochondrial damage is linked to a wide spectrum of human diseases, from devastating syndromic illnesses to neurodegeneration and autoimmunity. This project is focused on 1) how stresses such as cancer therapy or infection cause mitochondrial damage, and 2) understanding the biological processes that are triggered inside the cell as it tries to recover. It will give a much greater understanding of mitochondrial damage at the microscopic level, and has the potential to unlock new avenues of investigation into the causes of inflammatory and immune disorders.

人体是由线粒体提供能量的，线粒体是活细胞的微观组成部分，它们产生功能所需的能量。线粒体损伤与多种人类疾病有关，从毁灭性综合征疾病到神经变性和自身免疫。该项目的重点是1）癌症治疗或感染等压力如何导致线粒体损伤，以及2）了解细胞试图恢复时在细胞内触发的生物过程。它将在微观水平上对线粒体损伤有更深入的了解，并有可能开启调查炎症和免疫疾病原因的新途径。