Role of the Ets family transcription factor Erg in stem cell function and hematopoiesis

Ets家族转录因子Erg在干细胞功能和造血中的作用

• 批准号: nhmrc : 516726
• 负责人: Prof Benjamin Kile
• 金额: $ 27.59万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-ets-family-function-hematopoiesis/97149
• 关键词: Role; Ets; family; transcription; factor

The cells responsible for producing blood are called hematopoietic stem cells (HSCs). Our research is focused on the genes that control HSC growth and development. We have discovered that a gene known to cause cancer, Erg, plays a critical role in regulating this process. This Project will tease apart the mechanism by which it does so, provide insights into how Erg can trigger cancer, and help us understand the molecular network of regulators that control blood cell production.

负责造血的细胞被称为造血干细胞（hsc）。我们的研究重点是控制HSC生长和发育的基因。我们发现一种已知的致癌基因Erg在调节这一过程中起着关键作用。该项目将梳理其机制，为Erg如何引发癌症提供见解，并帮助我们了解控制血细胞产生的调节分子网络。