The role of oncogenes, cell death machinery and novel players in the regulation of hematopoietic stem cells, leukemogenesis and hematological disorders

癌基因、细胞死亡机制和新参与者在造血干细胞、白血病发生和血液疾病调节中的作用

• 批准号: nhmrc : 1063008
• 负责人: Prof Benjamin Kile
• 金额: $ 50.9万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-oncogenes-cell-hematological-disorders/455033
• 关键词: role; oncogenes; cell; death; machinery

This project is focused on the regulation of blood cells and the diseases that arise when they become defective, such as bone marrow failure and leukemia. It will investigate how proteins involved in cell suicide impact on blood cell survival, cancer therapy, and the formation of blood clots. The link between cancer genes and stem cells will be examined. Ultimately, the aims are to identify drug targets in hematological disorders, and develop new drugs to promote the survival of healthy cells.

该项目的重点是血细胞的调节和当它们变得有缺陷时出现的疾病，如骨髓衰竭和白血病。它将研究参与细胞自杀的蛋白质如何影响血细胞存活，癌症治疗和血栓形成。癌症基因和干细胞之间的联系将被研究。最终，目标是确定血液疾病的药物靶点，并开发新的药物来促进健康细胞的存活。