Role of calcium stores and phosphate channels in muscle fatigue

钙储存和磷酸盐通道在肌肉疲劳中的作用

• 批准号: nhmrc : 211030
• 负责人: Prof David Allen
• 金额: $ 14.78万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-calcium-stores-muscle-fatigue/100127
• 关键词: Role; calcium; stores; phosphate; channels

Muscles become weaker when ever they are used intensively; this is the familiar muscle fatigue. We are studying the mechanism of muscle fatigue and believe it is caused by depletion of a store of calcium inside the muscle. We suspect the store of calcium declines because phosphate, which is a product of muscle metabolism, enters the calcium store and precipitates as calcium phosphate. Currently we are trying to prove this hypothesis and extend it by studying the channels through which phosphate passes from the muscle cell into the calcium store. It may be possible to find or design drugs which minimise the movement of phosphate through this channel and such a drug might reduce the component of fatigue caused by this mechanism. Such a drug might benefit patients whose normal activities are limited by muscle fatigue; this includes patients with any disabling muscle disease, such as muscular dystrophy or stroke, and patients with heart failure. In addition elderly people suffer a loss of muscle bulk and the remaining muscle is easily fatigued causing loss of mobility and independence; so the elderly might also benefit from such a drug.

当肌肉被过度使用时，它会变弱；这就是我们所熟悉的肌肉疲劳。我们正在研究肌肉疲劳的机制，并认为这是由肌肉内钙储存的消耗引起的。我们怀疑钙的储存减少是因为肌肉代谢的产物磷酸盐进入钙储存并沉淀为磷酸钙。目前，我们正试图证明这一假设，并通过研究磷酸盐从肌肉细胞进入钙储存的通道来扩展它。有可能找到或设计药物，使磷酸盐通过这一通道的运动最小化，这样的药物可能会减少由这一机制引起的疲劳成分。这种药物可能对那些正常活动因肌肉疲劳而受限的患者有益；这包括患有任何致残性肌肉疾病的患者，如肌肉萎缩症或中风，以及心力衰竭患者。此外，老年人肌肉量减少，剩余肌肉容易疲劳，导致行动能力和独立性丧失；因此，老年人也可能从这种药物中受益。