The role of differentially methylated genes in the initiation and progression of colorectal cancers

差异甲基化基因在结直肠癌发生和进展中的作用

• 批准号: nhmrc : 145000
• 负责人: A/Pr Joanne Young
• 金额: $ 24.11万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-differentially-methylated-colorectal-cancers/76605
• 关键词: role; differentially; methylated; genes; initiation

Most colorectal cancers develop from polyps in the lining of the bowel. The bulk of cancers develop from adenomatous polyps, but we have found that a second type of polyp called a hyperplatic polyp can also be associated with the development of cancer. During our studies of these polyps we found that a particular gene was inactivated in all of these polyps. We have called this gene HPP1. HPP1 was also found to be inactivated in adenomatous polyps and about 50% of colorectal cancers, indicating that it may be an important player in the early stages of colorectal cancer and hence may allow opportunity for prevetive intervention. This grant proposal will investigate the function of HPP1 in the genesis of colorectal polyps and cancers.

大多数结直肠癌是由肠壁息肉发展而来的。大多数癌症是由腺瘤性息肉发展而来的，但我们发现第二种类型的息肉--增生性息肉--也可能与癌症的发生有关。在我们对这些息肉的研究中，我们发现一个特定的基因在所有这些息肉中都是失活的。我们称这个基因为HPP1。HPP1在腺瘤性息肉和大约50%的结直肠癌中也被发现失活，这表明它可能在结直肠癌的早期阶段发挥重要作用，因此可能为预防性干预提供了机会。这项拨款提案将研究HPP1在大肠息肉和癌症发生中的作用。