Role in disease of a novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44

与高毒力脑膜炎奈瑟菌克隆复合物相关的新型表观遗传调节因子在疾病中的作用 41/44

• 批准号: nhmrc : 1021631
• 负责人: A/Pr Kate Seib
• 金额: $ 26.89万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-disease-novel-complex-4144/110138
• 关键词: Role; disease; novel; epigenetic; regulator

Neisseria meningitis is a major cause of meningococcal septicaemia and meningitis worldwide. We have identified a phase variable DNA methyltransferase present in disease isolates, some of which have caused meningococcal epidemics. This methyltransferase is involved in the regulation of proteins involved in infection and disease processes. We will investigate whether this regulation increases the ability of the bacteria to adapt to changing host environments and cause disease.

脑膜炎奈瑟菌是世界范围内脑膜炎球菌败血症和脑膜炎的主要原因。我们已经确定了一个阶段可变的DNA甲基转移酶存在于疾病分离株，其中一些引起脑膜炎球菌流行。这种甲基转移酶参与感染和疾病过程中蛋白质的调节。我们将研究这种调节是否增加了细菌适应不断变化的宿主环境并引起疾病的能力。