Developing species-specific, structure-targeting peptides as a novel class of antibiotics

开发物种特异性、结构靶向肽作为一类新型抗生素

• 批准号: nhmrc : GNT1121629
• 负责人: A/Pr Kate Seib
• 金额: $ 60.8万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/developing-species-specific-class-antibiotics/1347214
• 关键词: Developing; species; specific; structure; targeting

Multidrug, antibiotic resistance is a serious global threat. It is a real possibility that in the absence of new antibiotics, common infections could soon become untreatable. This project will develop a novel class of antibiotics that target the core structures of essential bacterial proteins. The successful outcome of this work will also aid the development of specific peptide-based inhibitors for numerous additional diseases, including viral and fungal infections and cancer.

多药耐药性是一个严重的全球性威胁。在没有新抗生素的情况下，普通感染可能很快变得无法治愈，这是一种真实的可能性。该项目将开发一种新型抗生素，靶向细菌必需蛋白的核心结构。这项工作的成功结果也将有助于开发针对许多其他疾病的特异性肽基抑制剂，包括病毒和真菌感染以及癌症。