Novel epigenetic regulatory mechanisms in Moraxella catarrhalis and non-typeable Haemophilus influenzae: impact on vaccine development and role in pathobiology

卡他莫拉菌和不可分型流感嗜血杆菌的新型表观遗传调控机制：对疫苗开发的影响及其在病理生物学中的作用

• 批准号: nhmrc : GNT1099279
• 负责人: A/Pr Kate Seib
• 金额: $ 62.7万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-epigenetic-regulatory-role-pathobiology/1346047
• 关键词: Novel; epigenetic; regulatory; mechanisms; Moraxella

Moraxella catarrhalis (Mcat) and non-typeable Haemophilus influenzae (NTHI) are two major causes of middle ear infections in children, and respiratory disease in adults. This project aims to characterise novel regulatory mechanisms associated with disease isolates of these bacteria. This research will aid vaccine development by defining the repertoire of stably expressed potential vaccine targets of Mcat and NTHi, and will improve our understanding of host-pathogen interactions.

卡他莫拉菌（Mcat）和不可分型的流感嗜血杆菌（NTHI）是儿童中耳感染和成人呼吸道疾病的两个主要原因。该项目旨在描述与这些细菌的疾病分离株相关的新调控机制。这项研究将通过确定Mcat和NTHi稳定表达的潜在疫苗靶点来帮助疫苗开发，并将提高我们对宿主-病原体相互作用的理解。