Novel epigenetic regulatory mechanisms in Moraxella catarrhalis and non-typeable Haemophilus influenzae: impact on vaccine development and role in pathobiology
Novel epigenetic regulatory mechanisms in Moraxella catarrhalis and non-typeable Haemophilus influenzae: impact on vaccine development and role in pathobiology
批准号:
nhmrc : GNT1099279
负责人:
A/Pr Kate Seib
金额:
$62.7万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 --
中文摘要
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英文摘要
Moraxella catarrhalis (Mcat) and non-typeable Haemophilus influenzae (NTHI) are two major causes of middle ear infections in children, and respiratory disease in adults. This project aims to characterise novel regulatory mechanisms associated with disease isolates of these bacteria. This research will aid vaccine development by defining the repertoire of stably expressed potential vaccine targets of Mcat and NTHi, and will improve our understanding of host-pathogen interactions.
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