Vaccine discovery for human mucosal pathogens: identifying novel vaccine antigens that are stably expressed during host interactions, using analysis of cell-contact and phasevarion mediated expression profiles

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The control of several human pathogens depends on vaccine development due to antibiotic resistance and the devastating outcome of infection. This work aims to identify new vaccine targets for diseases including gonorrhoae, ear infections, meningitis and sepsis, based on proteins required for interaction with human cells. Proteins that are randomly switched on and off in these bacteria will also be studied to better understand disease and to rule out variably expressed genes from new vaccines.