Vaccine discovery for human mucosal pathogens: identifying novel vaccine antigens that are stably expressed during host interactions, using analysis of cell-contact and phasevarion mediated expression profiles

人类粘膜病原体的疫苗发现：利用细胞接触和相变介导的表达谱分析，鉴定在宿主相互作用期间稳定表达的新型疫苗抗原

• 批准号: nhmrc : 1045235
• 负责人: A/Pr Kate Seib
• 金额: $ 27.9万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/vaccine-discovery-human-expression-profiles/111728
• 关键词: Vaccine; discovery; human; mucosal; pathogens

The control of several human pathogens depends on vaccine development due to antibiotic resistance and the devastating outcome of infection. This work aims to identify new vaccine targets for diseases including gonorrhoae, ear infections, meningitis and sepsis, based on proteins required for interaction with human cells. Proteins that are randomly switched on and off in these bacteria will also be studied to better understand disease and to rule out variably expressed genes from new vaccines.

由于抗生素耐药性和感染的破坏性后果，对几种人类病原体的控制取决于疫苗的开发。这项工作的目的是根据与人体细胞相互作用所需的蛋白质，确定淋病、耳部感染、脑膜炎和败血症等疾病的新疫苗靶点。在这些细菌中随机打开和关闭的蛋白质也将被研究，以更好地了解疾病，并排除新疫苗中的非表达基因。