Identification of novel gonococcal virulence factors and vaccine antigens based on their expression during host cell contact and their role in association, invasion and survival in cervical epithelia

根据宿主细胞接触期间的表达及其在宫颈上皮细胞中的关联、侵袭和存活中的作用，鉴定新型淋球菌毒力因子和疫苗抗原

• 批准号: nhmrc : 1028326
• 负责人: A/Pr Kate Seib
• 金额: $ 24.8万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-novel-gonococcal-cervical-epithelia/110626
• 关键词: Identification; novel; gonococcal; virulence; factors

The sexually transmitted infection gonorrhoea is a significant health problem worldwide. Control of gonorrhoea depends on the development of a vaccine due to the continuing increase of antibiotic resistance and the staggering outcomes of infection, including infertility and increased transmission of HIV. My research aims to discover new vaccine targets by identifying gonococcal proteins that are required for interaction with human cervical cells.

性传播感染淋病是世界范围内的一个重大健康问题。淋病的控制取决于疫苗的开发，因为抗生素耐药性持续增加，感染的后果令人震惊，包括不孕症和艾滋病毒传播的增加。我的研究旨在通过鉴定与人宫颈细胞相互作用所需的淋球菌蛋白来发现新的疫苗靶点。