The role of H2-Q10 in liver immunity

H2-Q10在肝脏免疫中的作用

• 批准号: nhmrc : 1082261
• 负责人: Dr Daniel Andrews
• 金额: $ 31.28万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-h2-q10-liver-immunity/518864
• 关键词: role; H2; Q10; liver; immunity

The liver is an important organ in terms of immune responses. Owing to its exposure to many antigens, it is required to maintain a form of immune tolerance. This ensures that overt immune responses which would damage the liver do not occur. One means by which tolerance occurs is through silencing killer cells through the regulation of molecules of Major Histocompatibility Complex (MHC). This project will explore the role of a soluble form of MHC which is expressed only in the liver.

肝脏是免疫反应的重要器官。由于其暴露于许多抗原，因此需要维持一种形式的免疫耐受。这确保了不会发生会损害肝脏的明显免疫反应。耐受性发生的一种方式是通过调节主要组织相容性复合物（MHC）的分子来沉默杀伤细胞。这个项目将探索一种可溶性形式的MHC的作用，这种形式只在肝脏中表达。