Granzymes as regulators of inflammation

颗粒酶作为炎症调节剂

• 批准号: nhmrc : 628302
• 负责人: Dr Daniel Andrews
• 金额: $ 45.03万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/granzymes-regulators-inflammation/96822
• 关键词: Granzymes; regulators; inflammation

Inflammatory processes are normally regarded as being initiated and maintained through the activities of white blood cell macrophages. We propose to explore the role of lymphocyte delivery of protease molecules termed granzymes in inflammation. Our preliminary data has demonstrated a novel paradigm involving amplification of septic shock through the activity of granzymes. We now wish to exlore these interactions at a cellular and biochemical level as a means to better understand inflammation.

炎症过程通常被认为是通过白色血细胞巨噬细胞的活动启动和维持的。我们建议探讨淋巴细胞传递蛋白酶分子（称为颗粒酶）在炎症中的作用。我们的初步数据已经证明了一种新的模式，涉及通过颗粒酶的活性放大感染性休克。我们现在希望在细胞和生物化学水平上探索这些相互作用，以更好地理解炎症。