Regulation of natural killer cell homeostasis by multiple components of the immune system

免疫系统多个组成部分对自然杀伤细胞稳态的调节

• 批准号: nhmrc : 566602
• 负责人: Dr Daniel Andrews
• 金额: $ 21.81万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-natural-killer-components-immune/76227
• 关键词: Regulation; natural; killer; cell; homeostasis

Differentiation and homeostasis of immune cell populations such as CD4 and CD8 T cells and dendritic cells has been key to understanding their function during inflammation. In contrast, late stage natural killer (NK) cell differentiation has largely been ignored. Given the key role of NK cells in providing innate effector immunity and shaping adaptive responses, a better understanding of the cues that regulate their differentiation is clearly warranted.

免疫细胞群如CD4和CD8 T细胞和树突状细胞的分化和稳态是理解它们在炎症过程中功能的关键。相比之下，晚期自然杀伤（NK）细胞分化在很大程度上被忽视。鉴于NK细胞在提供先天效应免疫和形成适应性反应中的关键作用，显然有必要更好地了解调节其分化的线索。