Understanding Natural Killer Cell Development and Target Recognition

了解自然杀伤细胞的发育和目标识别

• 批准号: nhmrc : 1028425
• 负责人: Dr Daniel Andrews
• 金额: $ 27.23万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-natural-killer-target-recognition/110637
• 关键词: Understanding; Natural; Killer; Cell; Development

Immune detection and eradication or control of cancer and cancer immunotherapies are based in part on the idea that tumour-specific white blood cells can protect the body from tumour development, growth and metastases. While strong evidence supports this, the means by which these white cells first recognize the cancerous tissue is largely unknown. We will study a new family of white blood cell receptors that may be important in this recognition, either naturally or following therapy.

免疫检测和根除或控制癌症以及癌症免疫疗法部分基于肿瘤特异性白细胞可以保护身体免受肿瘤发展、生长和转移的想法。虽然强有力的证据支持这一点，但这些白细胞首先识别癌组织的方式在很大程度上尚不清楚。我们将研究一个新的白细胞受体家族，它们在这种识别中可能很重要，无论是自然的还是治疗后的。