The role of the NPY system in the regulation of appetite and satiety

饮食失调在肥胖和厌食症的发展中起到了致病作用，它带来了巨大的卫生保健问题，目前的预防方法和治疗方法并不令人满意。这里提出的研究将复杂的分子技术与最先进的生化和生理分析相结合。通过利用一组独特的小鼠模型(其中许多只对我们可用)，缺失或过度生产调节食欲和饱腹感的关键因素，这项研究将为理解这些疾病做出极具原创性和国际竞争力的贡献。这一结果将对肥胖症和厌食症的新诊断和潜在治疗方法的开发产生重大影响。此外，通过这笔赠款提供的资金不仅有助于找到这些重要问题的答案，还将为几种新型鼠标模型的产生提供基础。这些动物模型也将成为澳大利亚和世界范围内更广泛的科学界的有益工具。我们在转基因和基因敲除小鼠模型的产生和全面分析方面拥有成熟的记录，使这一建议不仅可行，而且极有可能成功，并为极其重要的健康问题提供了新的伟大见解。

Eating disorders that have a causative role in the development of obesity and anorexia present massive health care problems for which current preventive methods and therapies are unsatisfactory. The studies proposed here combine sophisticated molecular techniques with state-of-the-art biochemical and physiological analyses. By utilising a panel of unique mouse models (many of which are only available to us), missing or overproducing key factors in the regulation of appetite and satiety this research will make highly original and internationally competitive contributions to the understanding of these disorders. The results will have a significant impact on the development of novel diagnostics and potential treatments for obesity and anorexia. In addition, funding provided through this grant would not only help to find answers to these important questions but will also provide the basis for the generation of several novel mouse models. These animal models will also be beneficial tools for the wider scientific community here in Australia and worldwide. We have a proven record in the generation and comprehensive analysis of transgenic and knockout mice models making this proposal not only feasible but also highly likely to succeed and provide great new insight into extremely important health problems.