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The mechansim of cachexia induced by the TGF-b superfamily cytokine, MIC-1

The mechansim of cachexia induced by the TGF-b superfamily cytokine, MIC-1
TGF-b超家族细胞因子MIC-1诱导恶病质的机制
批准号:
nhmrc : 455291
负责人:
A/Pr Amanda Salis
金额:
$36.29万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2007
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2007-01-01 至 2009-12-31

项目摘要

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中文摘要
翻译
MIC-1是我们研究小组首次克隆和鉴定的蛋白质。它属于TGF β蛋白超家族,其在癌症、创伤-骨折愈合和炎症的发展中非常重要。最近的证据还表明,它可以作为一种食欲抑制剂,这是特别相关的条件下,如癌症,它是生产过剩。这个项目旨在了解其改变食欲的机制
英文摘要
MIC-1 is a protein first cloned and characterised by our research group. It belongs to the TGF beta protein superfamily which is very important in development of cancer, wound - fracture healing and inflammation. Recent evidence also suggests it can act as an appetite suppressant, and this is especially relevant in conditons like cancer where it is overproduced. This project seeks to understand the mechanisms for its capacity to modify appetite
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  • 项目类别:
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  • 项目类别:
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海外基金