Long-term effects of very low energy diet versus conventional diet on adiposity, lean body mass, muscle strength and bone density in obese adults, and mechanisms promoting changes

极低能量饮食与传统饮食对肥胖成人的肥胖、去脂体重、肌肉力量和骨密度的长期影响以及促进变化的机制

• 批准号: nhmrc : 1026005
• 负责人: A/Pr Amanda Salis
• 金额: $ 61.75万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/long-term-effects-promoting-changes/110461
• 关键词: Long; term; effects; very; low

Very low energy diets (VLEDs) are increasingly used to treat obesity. Of concern is the fact that VLEDs induce adaptive responses that can inhibit loss of – and promote regain of – fatness (particularly belly fat) while decreasing lean body mass, muscle strength and bone density. This project will therefore determine whether VLEDs could have negative effects on body composition that increase the risk of metabolic disease, sarcopenia or osteoporosis, and if so, what are the mechanisms involved.

极低能量饮食（VLED）越来越多地用于治疗肥胖症。值得关注的是，VLED诱导适应性反应，可以抑制脂肪（特别是腹部脂肪）的损失-并促进脂肪的恢复，同时降低瘦体重，肌肉力量和骨密度。因此，该项目将确定VLED是否会对身体成分产生负面影响，增加代谢疾病，肌肉减少症或骨质疏松症的风险，如果是这样，所涉及的机制是什么。