Improving weight loss by intermittent use of very low energy diet: the TANGO Diet Trial (Temporary phases of Accelerated weight loss for Noticeably Greater Outcomes)

通过间歇性使用极低能量饮食来改善减肥效果：TANGO 饮食试验（加速减肥的临时阶段，以获得明显更好的结果）

• 批准号: nhmrc : 1127737
• 负责人: A/Pr Amanda Salis
• 金额: $ 54.83万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/improving-weight-loss-greater-outcomes/948052
• 关键词: Improving; weight; loss; intermittent; use

Very low energy diet (VLED) is being increasingly used for the treatment of obesity, but the resultant weight loss is usually transient, partly because it induces powerful adaptive responses that inhibit weight loss and promote regain. We have shown that 'taking a break from dieting' for 2 weeks reduces these adaptive responses. In this project we will thus test whether weight loss outcomes with VLED can be improved via intermittent use, where periods on the VLED are alternated with 'breaks'.

极低能量饮食（VLED）越来越多地用于治疗肥胖症，但由此产生的体重减轻通常是短暂的，部分原因是它诱导了抑制体重减轻并促进体重恢复的强大适应性反应。我们已经证明，“从节食中休息一下”2周会减少这些适应性反应。因此，在这个项目中，我们将测试VLED的减肥效果是否可以通过间歇性使用来改善，其中VLED的周期与“休息”交替。