Cox regression model with change-point(s) problems and their application in cancer drug development

具有变点问题的Cox回归模型及其在癌症药物开发中的应用

• 批准号: 261844-2008
• 负责人: Ding, Keyue
• 金额: $ 1.02万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=395261
• 关键词: Cox; regression; model; change; point

This proposal is for developing and evaluating new statistical methods needed in cancer clinical trial practice, which will enable: 1) identifying cutoff points in predictive biomarkers or build gene signature classifier for cancer treatment selection; 2) better estimating treatment effect; 3) improved planning and analysis of clinical trials, and 4) study its implication in health economics. These methods will be implemented in the frame work of Cox regression models with change-point(s) problems.

这项建议是为了开发和评估癌症临床试验实践所需的新的统计方法，这将使：1)确定预测生物标志物的截止点或建立癌症治疗选择的基因标记分类器；2)更好地估计治疗效果；3)改进临床试验的规划和分析；4)研究其在卫生经济学中的意义。这些方法将在具有变点(S)问题的COX回归模型的框架中实现。