A strategic evolution of sequential tandem catalysis (STC) and concurrent tandem catalysis (CTC) protocols for applications in synthesis

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The property of chirality or "handedness" pervades the world in which we live. The phenomenon of molecular chirality, which refers to molecules that are identical in their connectivity but differ in their spatial arrangements, was first recognized by the Nobel Prize winner van't Hoff in 1874. Since then the phenomenon of molecular chirality has become of significant importance with the realization that molecules can have dramatically different physiological effects depending on their chirality. As such the ability to selectively prepare chiral molecules is therefore currently of pressing importance to chemists. The field of asymmetric catalysis ("Chiral Synthesis using Catalysts") is making this goal achievable through the use of small quantities of additives known as catalysts which selectively afford either "handed" isomer of a desired chiral compound.