Signaling pathways to enhance potency of AMPK-targeting drugs

增强 AMPK 靶向药物效力的信号通路

• 批准号: nhmrc : 1098459
• 负责人: Dr John Scott
• 金额: $ 45.37万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/signaling-pathways-enhance-targeting-drugs/662384
• 关键词: Signaling; pathways; enhance; potency; AMPK

Sedentary lifestyles and consumption of high energy foods has led to epidemics of obesity-related metabolic diseases that place enormous financial and medical burden on the Australian economy. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as both a cellular fuel gauge and co-ordinator of whole-body metabolism. Our goal is to improve AMPK drug potency by identifying novel processes that sensitize AMPK to drugs.

久坐不动的生活方式和高能量食物的消费导致了与肥胖相关的代谢疾病的流行，给澳大利亚经济带来了巨大的财政和医疗负担。AMP活化蛋白激酶（AMPK）是治疗这些疾病的一个有吸引力的药物靶点，它既是细胞燃料计量器，又是全身代谢的协调者。我们的目标是通过鉴定使AMPK对药物敏感的新过程来提高AMPK的药物效力。